The role of histamine in allergy is well-known. What may be less well-known or considered is that histamine can negatively impact immunity.1 During the histamine response process, inflammatory cytokines, including IL3, IL4, IL5, IL8, IL13, TNF-alpha, and prostaglandin E2, are produced and circulate through the system, causing inflammation, allergic symptoms, and in some cases, histamine intolerance.2 The deleterious effects of this process, when overactive, may be chronic unresolved inflammation and compromised immunity.1 2
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